ABSTRACT
La acatisia es un efecto lateral neurológico agudo común a diversos fármacos que actúan a nivel dopaminérgico, su manifestación fundamental es la inquietud psicomotora, es importante diagnosticar y tratar precozmente este síndrome. Tietilperazina es una fenotiazina cuyo efecto antiemético es usado en diversas circunstancias clínicas, presentamos el caso de una paciente hospitalizada por hiperemesis gravídica que es derivada a psiquiatría por la presencia de síntomas aparentemente ansiosos. El examen clínico permite sospechar acatisia por Tietilperazina Torecan®, el cuadro cede completamente con la suspensión del fármaco. Nos parece interesante comunicar este caso por la implicancia para los especialistas.
Akatisia is an common neurological complication of treatment with dopaminergic drugs, subjetive feeling of restlessness is their main symptom, it's important to recognize this syndrome early and to treat immediately. Thietylperazine is an phenothiazine drug with antiemetic effect used for medical practice, we present a case of 35 years old pregnancy inpatient referred to psychiatrist for anxiety, the diagnosis was akatisia induced by thietylperazide.
Subject(s)
Humans , Female , Pregnancy , Adult , Thiethylperazine/adverse effects , Akathisia, Drug-Induced/therapy , Antiemetics/adverse effectsABSTRACT
Na iminência de uma nova era na terapêutica psiquiátrica, com a redescoberta da clozapina e a introduçäo de novos antipsicóticos atípicos, é feito um balanço sistemático das substância desenvolvidas nos últimos 50 anos. As substâncias introduzidas até o presente säo reunidas nos grupos-tioxantênicos com estrutura aparentada às fenotiazinas), tioxantenos, butirofenonas, difenilbutilpiperidinas, benzamidas, indóis, dibenzoxazepinas - e nos grupos químicos mais recentes - dibenzodiazepinas, benzisoxazólicos, tienobenzodiazepinas, dibenzotiazepinas, benzisotiazólicos, didroindolonas, imidazolidinonas -, além de compostos ainda em desenvolvimento. Neste artigo, o segundo da série concebida com esta finalidade, säo examinados os derivados fenotiazínicos com cadeia lateral piperazínica, carfenazina, clorimpifenina, dixirazina, flufenazina, metofenazina, oxaflumazina, perazina, perfenazina, proclorperazina, tietilperazina, tiopropazato, tioproperazina e trifluperazina. Com base em bibliografia básica específica, säo discutidos aspectos técnicos e revisado o conhecimento cientíco acumulado através da experimentaçäo e da utilizaçäo clínica destes compostos, desde seu lançamento até a presente data, com informaçöes sistemáticas sobre fórmula estrutural, fórmula molecular, nomes químicos, nomes fantasia e códigos de cada composto, além de dados sobre sua eventual comercializaçäo no país
Subject(s)
Antipsychotic Agents , Perphenazine , Phenothiazines , Prochlorperazine , Thiethylperazine , Trifluoperazine , Drugs, GenericABSTRACT
BACKGROUND: Antihistamine drugs are used widely in many conditions. Although some antihistamines may cause a photosensitive reaction,many physicians are not awae of it. OBJECTIVE: For examination of the phototoxic potential of antihistamines, we performed the Candida albiecrns test which is simple, cheap, and good for the screening of many drugs. MEHTODS: Thirty microliters of each solute of various antihistamines were applied to the Sabraud dextrose agar plate in which Candida albicans were applied diffusly. Four hours after the application, 60J/cm fo UVA was irradiated for two days. The irradiated. plates and nonirradiated control ones were incubated in a dark room for 48 hours, and examined for lear zones arround the drug, which means a positive results for the phototoxic potential of the drugs. RESULTS: Mequitazine, thiethylperazine, perphenazine and cllorromazine showed positive results, whereas others did not. An additional Candida albicans test using 0.1%, 0.01%, and 0.001% of the positive drugs revealed tht chlorpromazine, thiethylperazine aderphenazine showed positive results at 0.1%, but negative at 0.01 and 0.001%. Mequitazine was niegative at 0.1, 0.01, and 0,001%, Additional studies of the Candida albicans test using 5% and 10% of the diphenhydramine and dimenhydrinate, those were known photosensitizers but they slowed negative results at this study and revealed very weak posit,ive result in 10% diphenhydramine. CONCLUSION: A photosensitive reaction such as photoallergy and persistent light react,ion may be triggered by the phenothiazine antihistamines. Negative result in 1%, and very weak positive results in 10% diphenhydramine may be due to different mechanism of phototoxicity, or the low phototoxic potential of diphenhydrainine.